When you take prescription or over-the-counter (OTC) medications, do you take also a vitamin, mineral, or other dietary supplements? Have you considered whether there is any danger in mixing medications and dietary supplements? It is widely highlighted that grapefruit juice affects the way your medicines work, especially if you have high blood pressure or arrhythmia (irregular or abnormal heart beat). It can effect other drugs a swell, but the severity of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink.
Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.
There is now further research that shows that grapefruit juice can also have the opposite effect. Fexofenadine an anti-histamine, instead of changing metabolism, grapefruit juice can affect proteins in the body known as drug transporters, which help move a drug into our cells for absorption. As a result, less of the drug enters the blood and the drug may not work as well. Orange Juice and apple juice also have the same effect with this medication so its important to always read the leaflet that comes with your medication.
St. John’s wort can decrease the effectiveness of birth control pills, leading to breakthrough bleeding and an increased risk of unintended pregnancy. It also interacts with anti – depressants, statins, and many others.
Herbs that decrease blood sugar may interact with anti-diabetes drugs to cause blood sugar to drop too far.
Echinacea a popular supplement at this time of year, but there are many interactions, especially with medications that follow the CYP3A4 pathway since these all have toxic effects on the liver.
There are lots of reports in news that as well as vitamin D being a common deficiency in the UK this is closely followed by magnesium, however magnesium tablets can interact with blood pressure tablets and antibiotics.
The list is not exhaustive, before you take any medication either prescribed or over the counter , vitamins, supplement or herbs please check for any interactions. Please also mention all medication, herbs, supplements and vitamins, to medical staff and your nutritionist.
© 2018 – Susan Monk BSc (Hons) Open, MFNTP.